ISOLATION, PURIFICATION AND CHARACTERIZATION OF HEMIDESMUS INDICUS R.BR. ROOT EXTRACT

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Anticarcinogenic and cytotoxic potential of Hemidesmus indicus root extract against Ehrlich Ascites tumor

The purpose of the present work was to evaluate anticarcinogenic and cytotoxic potential of Hemidesmus indicus methanolic root extract (HiRe) against Ehrlich Ascites Tumor. The extract showed a significant in vitro cytotoxic activity against Ehrlich Ascites Tumor (EAT) cell line. IC50 value for EAT cell line was 274.83μg.The anticarcinogenic activity of the extract was determined by using EAT c...

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AIM: This study was conducted to study the hepatoprotective property of Hemidesmus indicus (L.) R.Br. roots. METHODS: Hepatoprotective properties of the methanol extract of the roots of H. indicus var. pubescens were evaluated on paracetamol induced hepatotoxicity. Hepatotoxicity was induced in albino Wistar rats by the administration of paracetamol (1g/kg), p.o. for 7 days. Methanol extract of...

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Diabetes mellitus is a chronic metabolic disorder associated with hyperglycemia, oxidative stress and dyslipidemia. Hemidesmus indicus is employed as an indigenous medicine for a variety of ailments from earlier days. The present study was aimed to evaluate the role of Hemidesmus indicus in alloxan-induced experimental diabetic rats. The effect of oral administration of Hemidesmus indicus root ...

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Protective effect of Hemidesmus indicus R.Br. root extract against cisplatin-induced cytogenetic damage in mouse bone marrow cells

The aqueous extract of Hemidesmus indicus roots was investigated for its in vivo antigenotoxic effect against cisplatin-induced cytogenetic damage. Swiss albino mice were administered with various doses of the extract either singly (50, 100 and 200 mg/kg body weight) or as split doses (10, 20 and 40 mg/kg bw/day) for five consecutive days by oral gavage. As endpoints, chromosome aberrations, mi...

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Antidiabetic and antihypercholesterolemic effect of Hemidesmus indicus Linn.R. root in Alloxan induced diabetic rats

Antidiabetic and antihyperlipidemic effect of Hemidesmus indicus Linn.R.root. (HIR) was investigated in rats. Administration of HIR (40 mg/g body weight/day) for four weeks significantly decreased the serum cholesterol, triglyceride, free fatty acids and phospholipid. Four weeks treatment of diabetic rats with HIR (40 mg/g body weight/day) showed significant hypoglycemic effect. Results of the ...

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ژورنال

عنوان ژورنال: INTERNATIONAL RESEARCH JOURNAL OF PHARMACY

سال: 2014

ISSN: 2230-8407

DOI: 10.7897/2230-8407.050472